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                            磁性固相萃取在药毒物分析中的应用综述

                            时间:2019-01-15 来源:分析测试技术与仪器 作者:滕姣,陈学国,高原,王 本文字数:12107字

                              摘    要: 磁性固相萃取是一种新型的样品前处理技术,具有萃取时间短、吸附能力强、有机溶剂使用量少、操作简单快捷等优点,已经广泛应用于样品的分离提纯.在简要介绍磁性固相萃取技术发展、材料制备的基础上,着重对国内外磁性固相萃取技术在药毒物分析方面的发展现状以及应用进展进行了综述,以期为法庭科学领域相关物证鉴定提供参考,为严厉打击相关违法犯罪活动提供科学理论与实践依据.

                              关键词: 磁性固相萃取; 药物; 毒物分析;

                              Abstract: As a new typical sample pretreatment approach,magnetic solid-phase extraction(MSPE) has been widely applied in the separation and purification of complex samples,which has many advantages,including costing less extraction time and organic solvents,having higher absorption ability and simple and fast operation. The development of MSPE and materials were reviewed,and the application in toxicological analysis was also discussed in detail,aiming at provide reference for the trace evidence analysis in forensic science area and cracking down the drug crime.
                             

                            磁性固相萃取在药毒物分析中的应用综述
                             

                              Keyword: MSPE; drug; toxicological analysis;

                            星云棋牌官网下载   CIXINGGUXIANGCUIQU(magnetic solid-phase extraction,MSPE)SHIYIZHONGYICIXINGXIFUCAILIAOHUOZHEYIJINGBEICIHUADECAILIAOWEIXIFUJIJIZHIDEFENSANGUXIANGCUIQUJISHU,QICAOZUOLIUCHENGRUTU1SUOSHI[1].MSPEDEJIBENYUANLISHIZAIYANGPINDEXUANFUYEHUORONGYEZHONGJIARUCIXINGXIFUJIHOU,DAICEMUBIAOWUJIANGHUIBEIXIFUDAOCIXINGXIFUJIBIAOMIAN,SUIHOU,ZAIWAIBUCICHANGZUOYONGXIA,DAICEMUBIAOWUYUCIXINGXIFUJIYIQIBEIZHUANYIDAOQITARONGQIZHONG,ZUIZHONGTONGGUOHESHIDEXITUOJIXITUO,DAICEMUBIAOWUYUYANGPINRONGYEFENLI,CONGERDADAOFENLI、TICHUN、FUJIDEMUDE[2].ZUOWEIYIZHONGXINXINGYANGPINYUCHULIFANGFA,MSPEBUJINKEYIJIANSHAOYOUDU、YOUHAIYOUJIRONGJIDESHIYONGLIANGYUDUHAIXING,JIANHUAYANGPINYUCHULIGUOCHENG,BIMIANGUOLVHUOLIXINCAOZUO,YIYUSHIXIANZIDONGHUA,ERQIEHAIJUYOUFEICHANGGAODECUIQUNENGLI、FUJIBEISHUHETIQUXIAOLV[3].YUCHANGGUIDEGUXIANGCUIQU(SPE)XIANGBI,MSPESUOYONGDEXIFUJIKELIBIBIAOMIANJIDA,CUIQUKUOSANJULIDUAN,XIFUJIYONGLIANGSHAO,PINGHENGSHIJIANDUAN,BIMIANLECHUANTONGSPEXIFUJIXUZHUANGZHUHEYANGPINSHANGYANGDENGHAOSHIWENTI,ERQIEZAICHULISHENGWU、HUANJINGYANGPINSHIBUHUICUNZAISPEZHONGYUDAODEZHUDUSAIWENTI,SUOYIZAISHENGMINGKEXUE、CAILIAOKEXUE、HUANJINGKEXUEDENGZHUDUOLINGYUZHONGDOUDEDAOLEGUANGFANDEYINGYONG,ZHANSHILEGUANGKUODEYINGYONGQIANJING[4].

                              图1 磁性固相萃取操作流程示意图
                            图1 磁性固相萃取操作流程示意图

                              Fig.1 Schemetic diagram of operation procedure of magnetic solid-phase extraction

                              1 、磁性吸附材料

                            星云棋牌官网下载   CIXINGNAMICAILIAOSHIMSPEZHONGZUICHANGYONGDEXIFUCAILIAO,YIBANYOUCIXINGNAMILIZIHEBIAOMIANXIUSHIJILIANGBUFENZUCHENG,QIZUIDADETEDIANSHIKEYIYIJUBUTONGDEXUQIU,JIANGGEZHONGGONGNENGHUADECAILIAOXIUSHIYUCIXINGNAMIKELIBIAOMIAN,ZAICIXINGCAILIAOBIAOMIANJIANHESHANGBUTONGDEGUANNENGTUANHOU,KEYIYONGYUGEZHONGWUZHIZHONGBUTONGTEXINGFENXIWUDETIQU.CIXINGNAMILIZIJUYOUNAMICAILIAOZHUDUOXINGZHIDETONGSHI,HAIJUYOULIANGHAODEXIANGRONGXING、CIDAOXIANGXINGHEJIANGJIEXING,YIYUJIEHEDUOZHONGSHENGWUFENZIBINGJINXINGBIAOMIANXIUSHIDENGTEDIAN,JINGBIAOMIANXIUSHIJIXIUSHIHOUDECIXINGNAMICAILIAOSHUIRONGXINGHEFENSANXINGDADATIGAO,BIAOMIANNENGJIANGDI,BUYITUANJU.MUQIAN,CIXINGNAMICAILIAOZHIBEICHANGYONGFANGFAZHUYAOBAOKUOGONGCHENDIANFA、GAOWENREJIEFA、SHENGHUAXUEFA、RONGJIREFA、RONGJIAO-NINGJIAOFA、WEIRUYEFADENG,QIZHONGGONGCHENDIANFAYINGYONGZUIWEIGUANGFAN[5].YIJINGKAIFABINGYINGYONGDECIXINGXIFUCAILIAOBAOKUOHUOXINGTAN、TANNAMIGUAN、SHIMOXIDENGHEFENZIYINJI、JINSHU-YOUJIKUANGJIA(MOFs)DENGGAOFENZICAILIAO[6].

                              1.1、 磁性碳材料

                            星云棋牌官网下载   WANGLIMINDENG[7]YIHUOXINGTANWEIJIZHICAILIAO,TONGGUORONGJIREFAHECHENGCIXINGHUOXINGTAN,ZUOWEIFENSANJIZHIGUXIANGCUIQUDEXIFUCAILIAO,YONGLAIXIFUFUJISHUIYANGZHONGDEHENLIANGSHUANGFENA,JIEGUOLINGRENMANYI.HUZHENGYANDENG[1]TONGGUORONGJIREFANYINGZHIBEIDEDAOCIXINGDUOBITANNAMIGUAN,BINGYONGYUYINGYOUERPEIFANGNAIFENZHONGCANLIUDEXINGJISUDECUIQU,SUOJIANLIDEFANGFAKUAISU、JIANBIAN,SHIYONGYUYINGYOUERPEIFANGNAIFENZHONGXINGJISUCANLIUKUAISUSHAICHAYUJIANCE.WuDENG[8]TONGGUOHUAXUEGONGCHENDIANFAZHIBEILECIXINGSHIMOXIFUHECAILIAO,BINGJIANGQIYONGYUCUIQUHUANJINGSHUIYANGZHONGDEANJIJIASUANZHILEISHACHONGJI,MUBIAOFENXIWUDEFUJIYINZIYUANGAOYUFENSANYE-YEWEICUIQUHECHAOSHENGFUZHURUHUAWEICUIQUDECUIQUXIAOLV.

                              1.2 、磁性分子印迹材料

                              分子印迹聚合物是一种合成的具有选择性分子识别位点的稳定聚合物,磁性分子印迹聚合物结合分子印迹聚合物和磁性材料的优点,在目标物的识别与萃取方面具有更高的选择性.Wang等[9]选择利用分散聚合方法,选择2-(4,6-二氨基-1,3,5-三嗪-2-基胺)二硫乙烷作为模板分子,甲基丙烯酸为功能单体,乙二醇二甲基丙烯酸酯为交联剂,成功制备得到磁性分子印迹聚合物,并将其用于鸡蛋和奶类样品中灭蝇胺和三聚氰胺的提取与富集,试验结果显示出较高的选择性.作为当前分子印迹技术研究热点,表面分子印迹技术也在MSPE中得到了应用[10].苏立强等[11]以阿散酸为模板分子,选择2-乙烯吡啶为功能单体,以改性Fe3O4@SiO2为载体,通过表面印迹法合成阿散酸磁性分子印迹聚合物,结合紫外-可见吸收光谱法,实现了鸡肝中阿散酸的检测,制备的磁性分子印迹聚合物吸附性能良好、选择性强.

                              1.3、 磁性金属-有机框架材料

                              MOFs是一类由金属中心与有机配体经过自组装形成的具有可调节孔径的材料,与传统的无机多孔材料相比,MOFs具有更大的比表面积、更高的孔隙率,更加多样化的结构及功能[12].王志等[13]采用原位磁性功能化方法合成了一种具有磁性的功能化MOFs Fe3O4@SiO2-MOF-177星云棋牌官网下载,并将其用于环境水样中酚类化合物的分离富集,结果发现,该吸附材料提取效率高,富集倍数大.

                              2、 MSPE在药毒物分析中的应用

                            星云棋牌官网下载   ZUOWEIYIZHONGGAOXIAO、KUAISU、JIANBIANHEKEKAODEYANGPINTIQUYUFUJIJISHUFANGFA,MSPEWEIZHUDUOLINGYUZHONGHENLIANGFENXIWUDEFUJIDAKAILEYISHANXINDECHUANGHU,GEZHONGGONGNENGHUADECIXINGXIFUCAILIAOYUELAIYUEDUODEBEIKAIFABINGDEDAOGUANGFANYINGYONG.ZAIYAODUWUFENXIFANGMIAN,MSPEDEYINGYONGZHUYAOTIXIANZAIBUTONGYANGPINJIZHIZHONGGEZHONGBUTONGZHONGLEIDESHACHONGJI、CHUCAOJI、SHAJUNJI、ZHIWUSHENGZHANGDIAOJIEJIDENGNONGYAOJIKANGSHENGSU、ANMIANZHENJINGLEIHECHENGYAOWU、JINSHUDUWU、ZHIWUDUSU、DUPINDENGDETIQU、JINGHUAYUFUJI.

                              2.1 、农药分析

                              农药是一种化学药物,主要应用于农业生产过程中预防农业、牧业、林业中各种有害动植物和调节农作物的生长发育.目前我国使用的农药主要包括各种杀虫剂、除草剂、杀菌剂和植物生长调节剂等.由于这些农药在防止病虫害和调节农作物生长发育的同时,也在环境中大量的残留,对人类生命与正常生活、动植物的生长带来了不可估量的危害.同时,部分农药毒性较大,使用广泛易得,用于自杀、投毒以及误服所引起的案件也时有发生.因此,需要发展更加方便、快捷、准确的检测技术对各种不同样品中痕量农药进行检测,进而为相关案件侦破与诉讼提供有力的证据.杨露等[14]利用微波辅助法制备得到离子液体,又将离子液体修饰在磁性颗粒表面,获得Fe4O3@SiO2@ILs星云棋牌官网下载疏水化离子液体固定化的磁性球,结合液相色谱(HPLC)分析方法,建立了水样中有机磷类杀虫剂检测分析的MSPE-HPLC分析方法.试验结果显示:水样中3种有机磷类杀虫剂的分析相对偏差在3.6%~5.8%之间,R2大于0.999,定量限为1.699~3.144μg/m L,检测限为0.543~0.945μg/m L,研究表明该吸附剂对有机磷类杀虫剂具有良好的吸附性能.张凌怡等[15]将C18修饰的磁性纳米吸附材料用于水样中叶蝉散、甲草胺、毒死蜱、氟胺氰菊酯、氯菊酯、甲氰菊脂和氰戊菊脂的检测.试验结果表明:C18修饰的磁性纳米吸附材料稳定性好、可操作性强,在固相吸附过程中表现为样品极性越弱,回收率越高.通过优化试验条件,得到在0.1~10μg/L范围内的线性系数大于0.997 5,方法检出限范围在0.006~0.05μg/L,所建立的方法回收率高、标准偏差小、富集倍数大,可用于样品中低浓度非极性农药的定量和定性分析.姚伟宣等[16]使用Fe3O4修饰的多壁碳纳米管吸附剂提取蜂蜜中的拟除虫菊酯类农药,通过对离子强度、萃取和解析时间等因素优化选择后,得到最佳提取条件,结合气相色谱检测方法,目标物在0.5~50μg/L内线性相关性高,检出限范围为0.07~0.20μg/L,精密度在3.8%~8.1%之间,回收率高于78.4%,所建立的方法满足蜂蜜样品中残留杀虫剂检测的要求.邱霞琴等[17]利用RGO/Fe3O4磁性吸附材料与气相色谱-质谱联用检测瓜果蔬菜中的痕量拟除虫菊酯类农药,试验发现,RGO/Fe3O4磁性吸附剂对拟除虫菊酯类农药有较强的吸附作用,所建立的方法具有很好的相关性,4种拟除虫菊酯类农药检测线性相关系数为0.998~0.999,RSD值在4.3%~8.9%之间,检测限最低为2.05μg/kg,回收率为83.49%~117.38%.赵广莹等[18]使用磁性石墨烯与高效液相色谱法联用建立了测定水样中5种磺酰脲类除草剂的方法,经过多次试验优化得到最佳条件,所建立的方法定量分析相关系数在0.998 9~0.999 5之间,线性范围为0.05~50 ng/m L,检出限为0.005~0.04 ng/m L,加标回收率高达81.6%~97.0%,RSD低于6.3%,回收率与重现性较好,为磺酰脲类除草剂的检验开辟了一条新的途径.Peng等[19]将裸磁性Fe3O4纳米粒子与工业氨基官能化的多壁碳纳米管,在水中混合制备磁性氨基官能化多壁碳纳米管,然后其通过疏水和离子的相互作用,实现水样中的苯氧羧酸类除草剂的富集,结合液相色谱-串联质谱联用技术进行检测.试验表明,该方法测定的苯氧酸除草剂均能获得良好线性关系,检出限为0.01~0.02μg/L,在空白样品中加标3种浓度水平的7种苯氧羧酸类除草剂,回收率在92.3%~103.2%之间.该新型吸附材料具有良好的选择性,而且重复利用率高,可以快速、高效的实现苯氧酸类除草剂检测.何晓明等[20]采用原位共沉淀方法制备得到了β-环糊精磁性石墨烯纳米材料,结合液相色谱-质谱联用技术,建立了瓜果中9种植物生长调节剂的检测方法.试验发现,9种植物生长调节剂在相关范围内线性关系良好,相关系数高于0.999,检出限为1.03~3.42μg/kg,定量限为3.40~11.3μg/kg,基质加标回收率为71.7%~101%,相对标准偏差为0.9%~10.9%.所建立的分析检测方法,样品前处理操作简单,检测灵敏度高,结果准确性强,可实现瓜果中多种植物生长调节剂的同时快速测定.

                              2.2 、合成药物分析

                              MPSEZAIHECHENGYAOWUFENXIFANGMIANDEYINGYONGZHUYAOBAOKUOYILIAOWEISHENG、NONGYESHENGCHAN、CHUMUYANGZHIDENGLINGYUDEKANGSHENGSUJIANCE,QIANGJIE、QIANGJIAN、WUFU、TOUDU、ZISHAANJIANYIJIYILIAOJIUFENZHONGSHEJIDEANMIANZHENJINGLEIYAOWUDENGDEFENXI.YANGMENGHUIDENG[21]YIYOUBIGEWANTONGJIHEERYIXIJIBENXIUSHIDECIXINGNAMICAILIAOWEIXIFUJI,TIQUSHUIYANGZHONGDE4ZHONGHUANGANLEIKANGSHENGSU,SHIYONGYEXIANGSEPU-ZHIPULIANYONGFAJINXINGJIANCE.SHIYANJIEGUOBIAOMING,HUANGANLEIKANGSHENGSUZAI5~500μg/LNONGDUNEIJUYOULIANGHAODEXIANXINGFANWEI,XIANGGUANXISHUJUNDAYU0.999,JIANCHUXIANWEI4.2~4.7μg/L,JIABIAOHUISHOULVWEI72.3%~88.5%,XIANGDUIBIAOZHUNPIANCHAZAI3.5%~10.2%ZHIJIAN.GAIFANGFAJIANDANBIANJIE、YONGSHIDUAN、YOUJIRONGJIYONGLIANGSHAO、ZHONGXIANXINGHAO,KEYOUXIAODEYINGYONGYUYANGPINZHONGHENLIANGHUANGANLEIKANGSHENGSUDETIQUFENLI.LIXINYUEDENG[22]SHIYONGYIBUHECHENGFAHECHENGYOUCIXINGDESHIMOXI-GO-Fe3O4,ZUOWEIXIFUJI,YUGAOXIAOYEXIANGSEPU-ZHIPULIANYONGCEDINGSHUIZHONGDEKUINUOTONGLEIKANGSHENGSU,FAXIANLIZIQIANGDUDUICUIQUJIEGUOYINGXIANGWEIXIAO,JIABIAOHUISHOULVWEI80.75%~96.5%,QIEGAIFANGFACUIQUSHIJIANJIAODUAN、JIANCHUXIANJIAODI,DUIYUSHUIYANGPINZHONGHENLIANGKUINUOTONGLEIKANGSHENGSUDEJIANYANFENXIJUYOUYIDINGDEYOUYUEXING.CHENJIANHUDENG[23]SHIYONGFe3O4-SiO2-C18NAMICIXINGXIFUCAILIAOJIEHEQIXIANGSEPU-ZHIPULIANYONGJISHUCEDINGNIAOYEZHONGWEILIANGANMIANYAO,JIEHEZHENGJIAOSHEJI,TONGGUOJICHAFENXISHIYANFAXIANXIFUCAILIAODEYONGLIANGSHIZUIZHUYAODEYINGXIANGYINSU,QICISHICUIQUSHIJIAN.LIYONGSUOJIANLIDEFANGFAFENXINIAOYEZHONGDE9ZHONGANMIANYAO,HUISHOULVZUIGAOKEDA89.5%,C18XIUSHIDECIXINGNAMICAILIAODUIANMIANYAOJUYOULIANGHAODEXIFURONGLIANGHETIQUXIAOLV,MANZUSHIJIANJIANZHONGDUIANMIANYAODEJIANCEYAOQIU.WangDENG[24]JIYUYANGHUASHIMOXIHECHENGLEYIZHONGCIXINGNAMIFUHECAILIAO(Mg O),JIANGQIZUOWEICIXINGXIFUJI,YUGAOXIAOYEXIANGSEPUFALIANYONGDUIPINGGUOZHIZHONGBANGQUMEISU(PAT)JINXINGFUJIHECEDING.SHIYANFAXIAN,PINGGUOZHIZHONGPATJIANCHUXIANWEI2.3μg/kg,HUISHOULVZUIGAODADAO83.6%,ZHENGSHILESHIMOXIJICIXINGNAMIFUHECAILIAOSHIYIZHONGYONGYUPINGGUOZHIYANGPINPATFENXIDEYOUXIAOMSPECAILIAO.ZhangDENG[25]HECHENGZHIBEILECIXINGGU-XIANGANSUANJINSHU-YOUJIGUJIAFA,BINGYONGYUFUZAYANGPINZHONGBENERDANZHUOLEIANMIANZHENJINGYAOWUDEFENLIYUFUJI.JIEGUOBIAOMING,ZAIZUIJIATIAOJIANXIA,JIEHEYEXIANGSEPU-ZHIPUFA,NIAOYEHEFEISHUIYANGPINZHONGBENERDANZHUOLEIANMIANZHENJINGYAOWU,LAOLAXIPANDEZHILIANGNONGDUWEI10~50 000 ng/L,YITAZUOLUN、LVDANZHUO、APUZUOLUN、MIDAZUOLUNHESANZUOLUNDEZHILIANGNONGDUWEI5~50 000 ng/LSHI,JIANCHUXIANFANWEIWEI0.71~2.49 ng/L,ZAINIAOYEHEFEISHUIZHONGDEHUISHOULVFENBIEWEI80.2%~94.5%HE84.1%~94.4%.YOUCIKEJIAN,CIXINGGU-XIANGANSUANJINSHU-YOUJIGUJIACAILIAOKEYIYONGYUNIAOYEHEFEISHUIZHONGBENBINGERDANZAZHUOLEIYAOWUDETIQUYUFUJI.

                              2.3 、金属毒物分析

                              金属毒物是指能够引起慢性、急性中毒的金属单质及其化合物,与日常生产、生活密不可分,来自工业生产的重金属离子排放到环境,不仅会对人类活动造成严重影响,同时通过食物链进入人体,危害人类健康.因此,有必要对食品、环境样品中的有毒金属进行检测,确保食品安全[26].另外,大多数金属毒物无色无味,摄入少量即可导致中毒,因此,金属中毒的事件和案件时有发生.所以,对金属毒物检测技术研究不容忽视,MSPE在金属毒物分析方面也得到广泛应用.王芹等[27]合成得到Fe3O4/多壁碳纳米管/壳聚糖磁性纳米材料,以此为吸附剂,与火焰原子吸收光谱法联合使用测定工业废水中的Cu2+.试验结果表明:Cu2+线性范围在0.1~30.0μg/L之间,检出限为0.012μg/L,富集倍数最高可达40,样品回收率高,相对标准偏差小于4%.所建立的方法所需试剂量少,吸附剂选择性强、平衡速度快、容量大,具有较高的灵敏度和准确性,在废水中金属离子的检验方面具有良好的应用前景.俞梁敏等[28]利用吡啶类离子液体功能化的环糊精聚合物修饰于磁核表面,得到Fe3O4@ILs-CDCP磁性纳米材料,结合电感耦合等离子体发射光谱法检测水体中的铅和锑,综合考察p H值、洗脱剂浓度、类型和用量、共存离子干扰、样品体积等因素,得到方法检出限为1.50 ng/m L和0.54 ng/m L,实际回收率满足回收要求,该萃取方式效率高、分离时间短,可以用于水样中铅和锑的分析和检验.李蕾等[29]合成巯基化石墨烯和双硫腙功能化磁性氧化石墨烯新型吸附剂,分别建立了新型类浊点萃取技术和磁性固相萃取技术,同时与HPLC-ICP-MS联用对水和大米中的汞进行富集和检测,通过比较发现,磁性固相萃取技术中无机汞和甲基汞的富集因子明显高于浊点萃取技术,具有更低的检出限、较宽的线性范围,在汞形态痕量检测以及重金属目标物提取方面具有较大的优势.黄培婷等[30]以两步法合成的离子液体负载修饰磁性纳米材料Fe4O3@SiO2@CnMIMPF6为吸附剂,在最优的富集条件下对河水中的铬离子进行提取,利用火焰原子吸收分光光度法分析,结果发现,铬离子检出限为6.5μg/L,水样回收率大于95%,所建立的方法满足污水处理的检测要求.

                              2.4、 植物毒素分析

                              ZHIWUDUSUSHITIANRANCUNZAIYUZHIWUZHONGDUIREN、DONGWUYOUDUDEYILEIWUZHI,ZHONGDU、TOUDUANJIANSHIYOUFASHENG.XUDAN[31]CAIYONGLIYONGSHIERWANJIHUANGSUANNABAOFUDEFe3O4NAMILIZIXIFUJIAOSHUFENSANGUXIANGCUIQUJIEHEHPLC-UVFENLIHEFUJIGEGENQINLIANKOUFUYEZHONGDEXIAOBOJIAN、HUANGLIANJIANHEBAMATING.JIEGUOBIAOMING,YAOGENJIAN、HUANGLIANJIAN、BAMATINGHEXIAOBOJIANJUNJUYOULIANGHAODEXIANXINGGUANXI,R2JUNDAYU0.999,HUISHOULVWEI86.1%-99.2%,XIANGDUIBIAOZHUNPIANCHAJUNDIYU4.4%,SUOJIANLIDEFANGFAJUYOUZHUANGZHIJIANDAN、CAOZUOFANGBIAN、HUANJINGYOUHAO、JIAGEDILIANDENGYOUDIAN.

                              2.5、 毒品分析

                            星云棋牌官网下载   JINNIANLAI,GUOJIDUCHAOCHIXUFANLAN,WEILENENGGENGYOUXIAODEEZHIDUPINLANYONG、DAJIDUPINWEIFAFANZUI,XUYAOFAZHANXINGZHIYOUXIAO、QIESHIKEXINGDEJIANYANJISHU.XUFEIDENG[32]SHEJIZHIBEILEYIZHONGJINGANGWANANXINGCIXINGXIFUCAILIAO,JIEHECHAOKUAISUYEXIANGSEPUCHUANLIANZHIPUFENXIFANGFA,SHIXIANLEHUOGUODILIAOZHONGYINGSUJIAN、MAFEI、NEIKEDING、KEDAIYINHEDIBAYINDEKUAISUFENLIYULINGMINFENXI,PINGJUNHUISHOULVWEI65.6%~104.7%,RSDWEI4.2%~6.1%,JIANCHUXIANWEI0.75~7.5μg/kg,DINGLIANGXIANWEI2.5~25.0μg/kg.ChenDENG[33]YIFe3O4/SiO2/poly(MAA-co-EDMAWEICIXINGXIFUJI,JIYUMAOXIGUANDIANYONG,FAZHANLEYIZHONGGAOTONGLIANG、KUAISUDECIXINGGUXIANGCUIQU-MAOXIGUANDIANYONG(MSPE-CZE)JIANCELVANTONG、JIAJIBENBINGAN、APIANLEIDUPINJIQIDAIXIEWUDEFANGFA,CIXINGGUXIANGCUIQUZAI2 minNEIWANCHENG,CZEFENXI15 minWANCHENG.8ZHONGDUPINDEJIANCEXIANXINGFANWEIWEI0.015~0.105μg/m L,HUISHOULVJIEYU85.4%~110.1%ZHIJIAN,RINEI、RIJIANJINGMIDUFENBIEXIAOYU10.3%HE12.4%.

                              3、 存在的问题

                              MSPEZAIFUZAYANGPINYUCHULIFANGMIANDEYINGYONG,ZHENGMINGLEQICAOZUOJIANDAN、KUAISU、GAOXIAO、FUJIBEISHUGAODENGYOUSHI,DANZAIYAODUWUFENXIDEYINGYONGZHONGCUNZAIYIXIAWENTI:SHOUXIANSHIYINGYONGDUIXIANGWENTI,MSPEZAIZHURUHUANJINGSHUI、SHUCAI、TURANGDENGCHULISHI,ZAZHIGANRAOSHAO,DANDANGYINGYONGYUXUEYE、NIAOYE、ZUZHIDENGSHENGWUYANGPINSHI,CUNZAIJIZHIGANRAODA、TIQUXIAOLVJIAODIDENGWENTI.QICI,MSPEXIFUJIZHONGLEIFANDUO、GONGNENGGEYI,TONGYONGXINGBUQIANG,RUHEYOUZHENDUIXINGDEXUANZEHESHIDEXIFUJICAILIAO,XUYAOHUAFEIDALIANGDERENLIWULI.ZUIHOU,ZIDONGHUACHENGDUBUGAO,MSPECAOZUOWANQUANYIKAORENGONGJINXING,WUFASHIXIANZIDONGHUA、GAOTONGLIANGCAOZUO,RUONENGYANZHICHUXIANGYINGDEZIDONGMSPEZHUANGZHIJIANGHUIDADATIGAOQIYINGYONGLINGYUYUSHIYONGFANWEI.

                              4、 展望

                            星云棋牌官网下载   CIXINGGUXIANGCUIQUJISHUJIEJUELEPUTONGGUXIANGCUIQUXIFUJIZHUANGZHUHEDATIJISHANGYANGDEBIDUAN,JUYOUCUIQUSHIJIANDUAN、XIFUNENGLIQIANG、YOUJIRONGJISHIYONGLIANGSHAO、CAOZUOJIANDANDENGYOUDIAN,CONGERCHENGWEIGELINGYUZHONGYINGYONGGUANGFANDEYANGPINYUCHULIJISHU.DANTONGSHI,YECUNZAIMOUXIECIXINGGAOFENZIJUHEWUZHIBEIGUOCHENGFUZA、XIFUCUIQUZHONGXIANXINGYUXUANZEXINGDI、ZIDONGHUACHENGDUBUGAODENGQUEDIAN,YINCI,YANJIUGAOXUANZEXING、GAOXIFUXING、DICHENGBEN、SHIYONGFANWEIGUANG、KEZHONGFUSHIYONG、XINYINGDEXIFUJIJIANGSHIMSPEJISHUDEYANJIUFANGXIANG.

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                              滕姣,陈学国,高原,王越.药毒物分析中磁性固相萃取技术的应用进展[J].分析测试技术与仪器,2019,25(04):252-259.
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